IRF2BPL

Across TCGA cell cohorts, IRF2BPL mutation is significantly associated with the RNA expression of many other genes, with 107 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IRF2BPL-associated genes across cancer lineages are OR8D2, OR2W5, and XAGE5. Each is linked with IRF2BPL in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF2BPL-to-partner and partner-to-IRF2BPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8D2 grouped by IRF2BPL-low versus IRF2BPL-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF2BPL→partner) and Y-score (partner→IRF2BPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OR8D2 →	+0.161	+4.017	<.001	.007	3	2
OVARY	OR2W5 →	+0.040	+3.017	<.001	.006	3	2
BLOOD_Lymphoma	XAGE5 →	+0.433	+4.058	<.001	.009	3	2
BLOOD_Lymphoma	OR56A3 →	+0.379	+3.523	<.001	.009	3	2
BLOOD_Lymphoma	TRIM77 →	+0.022	+4.662	<.001	.003	3	2
BLOOD_Leukemia	OR6C3 →	+0.012	+3.762	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 107 associations by consensus.

OR8D2 by IRF2BPL expression — OESOPHAGUS

Explore this box plot interactively →