IRF2BP2

Across TCGA patient cohorts, IRF2BP2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRF2BP2-associated genes across cancer lineages are eIF4E, MEK1, and Notch1. Each is linked with IRF2BP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF2BP2-to-partner and partner-to-IRF2BP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by IRF2BP2-low versus IRF2BP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF2BP2→partner) and Y-score (partner→IRF2BP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.218	+3.321	.048	.010	3	1
UCEC	MEK1 →	+0.615	+3.321	.001	.010	3	1
UCEC	Notch1 →	+0.215	+2.820	.003	.035	3	1
UCEC	p90 RSK →	+0.217	+2.183	.030	.035	3	1
UCEC	Cyclin-B1 →	+0.613	+3.321	.037	.010	3	1
UCEC	ACC1 →	+0.460	+3.321	.015	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

eIF4E by IRF2BP2 expression — UCEC

Explore this box plot interactively →