IRF2BP1

Across TCGA patient cohorts, IRF2BP1 mutation is significantly associated with the RNA expression of many other genes, with 2,586 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRF2BP1-associated genes across cancer lineages are PLEKHM2, VARS2, and CBY1P1. Each is linked with IRF2BP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF2BP1-to-partner and partner-to-IRF2BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLEKHM2 grouped by IRF2BP1-low versus IRF2BP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF2BP1→partner) and Y-score (partner→IRF2BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLEKHM2 →	+0.382	+3.483	.007	.002	3	2
UCEC	VARS2 →	+0.392	+2.332	.006	.003	3	2
SKCM	CBY1P1 →	+0.045	+3.897	<.001	.009	3	2
LUAD	LINC01318 →	+0.139	+5.631	.002	.004	3	2
LUAD	LINC02214 →	+0.073	+5.481	<.001	.005	3	2
LUSC	BLOC1S2P1 →	+0.087	+3.279	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,586 associations by consensus.

PLEKHM2 by IRF2BP1 expression — UCEC

Explore this box plot interactively →