IRF2BP1

Across TCGA patient cohorts, IRF2BP1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRF2BP1-associated genes across cancer lineages are Ku80, MEK1, and p62 Lck ligand. Each is linked with IRF2BP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF2BP1-to-partner and partner-to-IRF2BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by IRF2BP1-low versus IRF2BP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF2BP1→partner) and Y-score (partner→IRF2BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.344	+3.179	.001	.010	3	1
UCEC	MEK1 →	+0.459	+3.459	.005	.005	3	1
UCEC	p62 Lck ligand →	+0.539	+3.594	<.001	.001	3	1
UCEC	PDCD4 →	-0.623	-2.000	.003	.032	3	1
UCEC	AMPK_pT172 →	+0.477	+2.713	.010	.003	3	1
UCEC	Annexin-1 →	+0.612	+3.189	.009	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Ku80 by IRF2BP1 expression — UCEC

Explore this box plot interactively →