IRF2BP1

Across TCGA cell cohorts, IRF2BP1 mutation is significantly associated with the RNA expression of many other genes, with 758 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IRF2BP1-associated genes across cancer lineages are SMIM18, TNP1, and RLN3. Each is linked with IRF2BP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF2BP1-to-partner and partner-to-IRF2BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM18 grouped by IRF2BP1-low versus IRF2BP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF2BP1→partner) and Y-score (partner→IRF2BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SMIM18 →	+0.140	+2.954	<.001	.001	3	2
SOFT_TISSUE	TNP1 →	+1.481	+5.369	<.001	.004	3	1
SOFT_TISSUE	RLN3 →	+0.041	+5.369	<.001	.004	3	1
SOFT_TISSUE	KRTAP29-1 →	+0.022	+5.369	<.001	.004	3	1
SOFT_TISSUE	PRAMEF18 →	+0.026	+4.930	<.001	.008	3	1
URINARY_TRACT	NRSN1 →	+0.153	+3.893	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 758 associations by consensus.

SMIM18 by IRF2BP1 expression — LARGE_INTESTINE

Explore this box plot interactively →