IRF2

Across TCGA patient cohorts, IRF2 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,824 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IRF2-associated proteins across cancer lineages are UBA7, CASP3, and FMNL1. Each is linked with IRF2 in more than 7 cancer types. Because this analysis shows association rather than direction, both IRF2-to-partner and partner-to-IRF2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRF2 versus UBA7 in HNSC, with a Pearson correlation of 0.31.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF2→partner) and Y-score (partner→IRF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	UBA7 →	+0.377	+0.580	<.001	<.001	3	8
OV	CASP3 →	+0.345	+0.526	<.001	<.001	3	7
OV	FMNL1 →	+0.519	+0.508	<.001	.003	3	7
OV	PSMB10 →	+0.435	+0.521	<.001	<.001	3	7
CCRCC	PSMB6 →	-0.500	-0.341	<.001	<.001	3	7
OV	PSMB5 →	-0.463	-0.477	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,824 associations by consensus.

IRF2 vs UBA7 — HNSC

Explore this scatter interactively →