IRF2

Across TCGA patient cohorts, IRF2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRF2-associated genes across cancer lineages are ASNS, FoxM1, and Acetyl-a-Tubulin-Lys40. Each is linked with IRF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both IRF2-to-partner and partner-to-IRF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by IRF2-low versus IRF2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF2→partner) and Y-score (partner→IRF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.526	+2.815	.015	.036	3	3
UCEC	FoxM1 →	+0.281	+2.321	.002	.001	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.383	+1.584	.036	.019	3	2
UCEC	MEK1 →	+0.401	+2.321	.002	.001	3	2
UCEC	PKC-b-II_pS660 →	-0.242	-1.807	.015	.025	3	2
UCEC	4E-BP1 →	+0.363	+2.936	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ASNS by IRF2 expression — COAD

Explore this box plot interactively →