IRF2

Across TCGA cell cohorts, IRF2 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible IRF2-associated genes across cancer lineages are OR4N2, SULT1C3, and UBTFL1. Each is linked with IRF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF2-to-partner and partner-to-IRF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4N2 grouped by IRF2-low versus IRF2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF2→partner) and Y-score (partner→IRF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OR4N2 →	+0.008	+4.029	<.001	.007	3	1
PANCREAS	SULT1C3 →	+0.220	+3.491	<.001	.008	3	1
PANCREAS	UBTFL1 →	+0.012	+4.029	<.001	.007	3	1
PANCREAS	SLC5A8 →	+0.004	+4.029	<.001	.007	3	1
PANCREAS	ELOA3CP →	+0.044	+4.035	.001	.003	3	1
PANCREAS	CBLN4 →	+0.004	+4.029	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

OR4N2 by IRF2 expression — PANCREAS

Explore this box plot interactively →