IRF1

Across TCGA pan-cancer cohorts, IRF1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated IRF1 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IRF1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IRF1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

UCEC, LSCC, and HNSC are the cancer types where IRF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.333	1.000	.006	24	view →
LSCC	DFS	Median	All	0.852	0.401	.020	4	view →
HNSC	OS	Median	III,IV	0.406	0.730	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

IRF1–UCEC (DFS)

Open the UCEC breakdown →