IRF1

Across TCGA patient cohorts, IRF1 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,605 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IRF1-associated proteins across cancer lineages are GBP1, GBP4, and GBP5. Each is linked with IRF1 in more than 9 cancer types. Because this analysis shows association rather than direction, both IRF1-to-partner and partner-to-IRF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRF1 versus GBP1 in HNSC, with a Pearson correlation of 0.63.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF1→partner) and Y-score (partner→IRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GBP1 →	+0.978	+1.120	<.001	<.001	3	10
HNSC	GBP4 →	+0.913	+1.111	<.001	<.001	3	10
HNSC	GBP5 →	+1.101	+1.110	<.001	<.001	3	10
HNSC	LAP3 →	+0.691	+0.999	<.001	<.001	3	10
UCEC	APOL3 →	+0.939	+0.799	<.001	.001	3	10
BRCA	PARP14 →	+0.423	+0.842	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,605 associations by consensus.

IRF1 vs GBP1 — HNSC

Explore this scatter interactively →