IRF1

Across TCGA patient cohorts, IRF1 protein abundance is significantly associated with the RNA expression of many other genes, with 4,606 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IRF1-associated genes across cancer lineages are PPP1R16B, PARP14, and ARHGAP9. Each is linked with IRF1 in more than 5 cancer types. Because this analysis shows association rather than direction, both IRF1-to-partner and partner-to-IRF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IRF1 versus PPP1R16B in HNSC, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF1→partner) and Y-score (partner→IRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PPP1R16B →	+1.281	+0.521	<.001	<.001	3	5
OV	PARP14 →	+1.254	+0.452	.008	.002	2	6
BRCA	ARHGAP9 →	+1.002	+0.721	<.001	<.001	3	5
HNSC	PIK3R5 →	+0.771	+0.429	.002	.001	3	5
LSCC	WAS →	+0.766	+0.966	<.001	<.001	3	5
HNSC	SLA →	+1.048	+0.447	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,606 associations by consensus.

IRF1 vs PPP1R16B — HNSC

Explore this scatter interactively →