IRF1

Across TCGA patient cohorts, IRF1 mutation is significantly associated with the RNA expression of many other genes, with 2,731 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRF1-associated genes across cancer lineages are MIR206, RN7SL465P, and RNU6-1137P. Each is linked with IRF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF1-to-partner and partner-to-IRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR206 grouped by IRF1-low versus IRF1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF1→partner) and Y-score (partner→IRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR206 →	+0.227	+5.111	<.001	.004	3	2
CESC	RN7SL465P →	+0.093	+6.000	<.001	<.001	3	2
CESC	RNU6-1137P →	+0.249	+4.384	<.001	.008	3	2
CESC	TRMT10BP1 →	+0.283	+3.653	<.001	.009	3	2
CESC	S100A11P9 →	+0.526	+3.760	<.001	.007	3	2
BLCA	RNU6-1133P →	+0.364	+4.788	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,731 associations by consensus.

MIR206 by IRF1 expression — HNSC

Explore this box plot interactively →