IRF1

Across TCGA patient cohorts, IRF1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRF1-associated genes across cancer lineages are JNK2, p62 Lck ligand, and PCNA. Each is linked with IRF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRF1-to-partner and partner-to-IRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by IRF1-low versus IRF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF1→partner) and Y-score (partner→IRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.371	+3.026	<.001	.018	3	1
UCEC	p62 Lck ligand →	+0.495	+2.321	.002	.035	3	1
UCEC	PCNA →	+0.272	+2.321	.012	.035	3	1
UCEC	Shc_pY317 →	-0.202	-3.000	.008	.036	3	1
UCEC	STAT3_pY705 →	-0.465	-2.321	<.001	.035	3	1
UCEC	ATM →	-0.711	-2.321	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

JNK2 by IRF1 expression — UCEC

Explore this box plot interactively →