IRF1

Across TCGA cell cohorts, IRF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,702 significant associations in total. BONE shows the largest number of these associations.

The most reproducible IRF1-associated GO terms across cancer lineages are Antigen processing and presentation of endogenous antigen, Antigen processing and presentation of peptide antigen via MHC class I, and Regulation of cytokine-mediated signaling pathway. Each is linked with IRF1 in more than 17 cancer types. Because this analysis shows association rather than direction, both IRF1-to-partner and partner-to-IRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antigen processing and presentation of endogenous antigen grouped by IRF1-low versus IRF1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRF1→partner) and Y-score (partner→IRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Antigen processing and presentation of endogenous antigen →	+0.317	+2.073	<.001	<.001	3	18
SOFT_TISSUE	Antigen processing and presentation of peptide antigen via MHC class I →	+0.225	+2.589	<.001	<.001	3	18
PANCREAS	Regulation of cytokine-mediated signaling pathway →	+0.085	+1.478	<.001	<.001	3	18
CNS	Positive regulation of defense response to virus by host →	+0.104	+1.381	<.001	.001	3	18
UPPER_AERODIGESTIVE_TRACT	Regulation of response to cytokine stimulus →	+0.098	+2.003	<.001	<.001	3	17
BREAST	Antigen processing and presentation of endogenous peptide antigen via MHC class I →	+0.304	+1.884	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,702 associations by consensus.

Antigen processing and presentation of endogenous antigen by IRF1 expression — BREAST

Explore this box plot interactively →