IREB2

Across TCGA patient cohorts, IREB2 protein abundance is significantly associated with the RNA expression of many other genes, with 10,525 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IREB2-associated genes across cancer lineages are TFRC, SHISAL1, and CIAO2A. Each is linked with IREB2 in more than 7 cancer types. Because this analysis shows association rather than direction, both IREB2-to-partner and partner-to-IREB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IREB2 versus TFRC in HNSC, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IREB2→partner) and Y-score (partner→IREB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TFRC →	+1.241	+0.350	<.001	<.001	3	8
UCEC	SHISAL1 →	-0.747	-0.308	.007	.006	3	6
COAD	CIAO2A →	+0.625	+0.390	<.001	<.001	3	6
OV	ZWILCH →	+0.561	+0.431	.001	<.001	3	6
OV	PSMA4 →	+0.828	+0.416	<.001	<.001	3	6
GBM	FXYD6 →	-1.094	-0.348	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,525 associations by consensus.

IREB2 vs TFRC — HNSC

Explore this scatter interactively →