IREB2

Across TCGA cell cohorts, IREB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,697 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible IREB2-associated GO terms across cancer lineages are Positive regulation of mRNA metabolic process, Regulation of transcription initiation by RNA polymerase II, and Transcription elongation by RNA polymerase II. Each is linked with IREB2 in more than 17 cancer types. Because this analysis shows association rather than direction, both IREB2-to-partner and partner-to-IREB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mRNA metabolic process grouped by IREB2-low versus IREB2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IREB2→partner) and Y-score (partner→IREB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of mRNA metabolic process →	+0.068	+0.742	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Regulation of transcription initiation by RNA polymerase II →	+0.079	+0.884	<.001	<.001	3	17
LIVER	Transcription elongation by RNA polymerase II →	+0.102	+0.851	<.001	<.001	3	17
OVARY	mRNA destabilization →	+0.061	+0.875	<.001	<.001	3	16
URINARY_TRACT	Copper ion export →	-0.223	-1.127	.001	.001	2	17
BONE	Regulation of mRNA catabolic process →	+0.062	+0.624	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,697 associations by consensus.

Positive regulation of mRNA metabolic process by IREB2 expression — BONE

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