IREB2

Across TCGA cell cohorts, IREB2 mutation is significantly associated with the RNA expression of many other genes, with 250 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IREB2-associated genes across cancer lineages are C6orf118, PRSS41, and CSN3. Each is linked with IREB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IREB2-to-partner and partner-to-IREB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by IREB2-low versus IREB2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IREB2→partner) and Y-score (partner→IREB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.097	+2.378	<.001	.006	3	2
SKIN	PRSS41 →	+0.052	+3.347	<.001	.005	3	1
BLOOD_Lymphoma	CSN3 →	+0.183	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP4-4 →	+0.024	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	HTR1A →	+0.029	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	TFDP3 →	+0.243	+4.523	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 250 associations by consensus.

C6orf118 by IREB2 expression — LARGE_INTESTINE

Explore this box plot interactively →