Across TCGA patient cohorts, IRAK4 protein abundance is significantly associated with the RNA expression of many other genes, with 13,271 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IRAK4-associated genes across cancer lineages are AHSA1, NEIL3, and NCAPH. Each is linked with IRAK4 in more than 3 cancer types. Because this analysis shows association rather than direction, both IRAK4-to-partner and partner-to-IRAK4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAK4→partner) and Y-score (partner→IRAK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AHSA1 →	-0.338	-0.146	.004	.003	3	4
UCEC	NEIL3 →	-0.809	-0.223	.005	.007	3	4
UCEC	NCAPH →	-0.802	-0.241	<.001	.002	3	4
LSCC	NDUFA10 →	-0.323	-0.302	<.001	<.001	3	4
COAD	CCDC85C →	-0.452	-0.199	.003	.002	3	4
BRCA	ZNF267 →	+0.662	+0.258	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,271 associations by consensus.

Exploration

IRAK4 survival (RNA) · tumor vs normal (RNA) · all IRAK4 data types