Across TCGA patient cohorts, IRAK4 mutation is significantly associated with the RNA expression of many other genes, with 926 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRAK4-associated genes across cancer lineages are CLUHP11, NDUFS6P1, and MIR4650-1. Each is linked with IRAK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRAK4-to-partner and partner-to-IRAK4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAK4→partner) and Y-score (partner→IRAK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CLUHP11 →	+0.329	+5.199	<.001	.003	3	2
COAD	NDUFS6P1 →	+0.142	+5.136	<.001	.002	3	2
BLCA	MIR4650-1 →	+0.368	+4.788	<.001	.006	3	2
UCEC	LINC01809 →	+0.119	+2.452	.001	.008	3	2
UCEC	ADH5P2 →	+0.096	+2.128	.006	.002	3	2
UCEC	ATP5F1EP1 →	+0.260	+2.139	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 926 associations by consensus.

Exploration

IRAK4 survival (RNA) · tumor vs normal (RNA) · all IRAK4 data types