Across TCGA patient cohorts, IRAK4 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRAK4-associated genes across cancer lineages are EGFR, FoxM1, and HSP70. Each is linked with IRAK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRAK4-to-partner and partner-to-IRAK4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAK4→partner) and Y-score (partner→IRAK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.153	-2.115	.028	.019	3	1
UCEC	FoxM1 →	+0.277	+2.807	.014	.003	3	1
UCEC	HSP70 →	-0.362	-2.990	.039	.036	3	1
UCEC	Ku80 →	+0.239	+3.179	.020	.010	3	1
UCEC	MEK1 →	+0.483	+3.906	.002	<.001	3	1
UCEC	p70-S6K →	+0.184	+2.833	.029	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

IRAK4 survival (RNA) · tumor vs normal (RNA) · all IRAK4 data types