Across TCGA cell cohorts, IRAK4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,680 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IRAK4-associated GO terms across cancer lineages are Canonical inflammasome complex assembly, Inflammasome-mediated signaling pathway, and Vesicle fusion. Each is linked with IRAK4 in more than 11 cancer types. Because this analysis shows association rather than direction, both IRAK4-to-partner and partner-to-IRAK4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAK4→partner) and Y-score (partner→IRAK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Canonical inflammasome complex assembly →	+0.157	+0.819	<.001	<.001	3	12
OVARY	Inflammasome-mediated signaling pathway →	+0.157	+0.819	<.001	<.001	3	12
BREAST	Vesicle fusion →	+0.060	+0.673	<.001	<.001	3	12
BREAST	Glycerophospholipid biosynthetic process →	+0.029	+0.595	.004	.002	2	12
BREAST	Membrane fusion →	+0.059	+0.687	<.001	<.001	3	11
BREAST	Organelle membrane fusion →	+0.057	+0.671	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,680 associations by consensus.

Exploration

IRAK4 survival (RNA) · tumor vs normal (RNA) · all IRAK4 data types