IRAK3

Across TCGA patient cohorts, IRAK3 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRAK3-associated genes across cancer lineages are MEK1, NF-kB-p65_pS536, and PCNA. Each is linked with IRAK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRAK3-to-partner and partner-to-IRAK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by IRAK3-low versus IRAK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAK3→partner) and Y-score (partner→IRAK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.345	+1.765	.006	.013	3	2
UCEC	NF-kB-p65_pS536 →	-0.379	-3.459	.016	.005	3	2
UCEC	PCNA →	+0.239	+2.459	.001	<.001	3	2
UCEC	PDCD4 →	-0.481	-1.575	.003	.034	3	2
UCEC	Rictor_pT1135 →	-0.082	-1.736	.020	.007	3	2
UCEC	Src_pY527 →	-0.388	-1.896	.009	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

MEK1 by IRAK3 expression — UCEC

Explore this box plot interactively →