IRAK3

Across TCGA cell cohorts, IRAK3 mutation is significantly associated with the RNA expression of many other genes, with 73 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IRAK3-associated genes across cancer lineages are CT47B1, CARD17, and MDGA2. Each is linked with IRAK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRAK3-to-partner and partner-to-IRAK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CT47B1 grouped by IRAK3-low versus IRAK3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAK3→partner) and Y-score (partner→IRAK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CT47B1 →	+0.022	+4.450	<.001	.004	3	2
OVARY	CARD17 →	+0.768	+4.228	<.001	.006	3	2
LARGE_INTESTINE	MDGA2 →	+0.123	+2.591	<.001	.008	3	2
BLOOD_Leukemia	OR1L6 →	+0.025	+4.060	<.001	.003	3	2
BLOOD_Leukemia	OR5V1 →	+0.013	+4.060	<.001	.003	3	2
BLOOD_Lymphoma	PLPPR1 →	+0.118	+3.459	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

CT47B1 by IRAK3 expression — OVARY

Explore this box plot interactively →