IRAK2

Across TCGA patient cohorts, IRAK2 mutation is significantly associated with the RNA expression of many other genes, with 2,934 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRAK2-associated genes across cancer lineages are H2BC2P, NDUFB6, and SPATA5L1. Each is linked with IRAK2 in more than 3 cancer types. Because this analysis shows association rather than direction, both IRAK2-to-partner and partner-to-IRAK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BC2P grouped by IRAK2-low versus IRAK2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAK2→partner) and Y-score (partner→IRAK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	H2BC2P →	+0.464	+5.554	<.001	.004	3	4
UCEC	NDUFB6 →	+0.447	+3.010	<.001	<.001	3	3
SKCM	SPATA5L1 →	+0.460	+2.523	.003	.009	3	3
SKCM	RN7SKP286 →	+0.026	+3.723	<.001	.009	3	3
STAD	PSMB6 →	+0.617	+3.271	<.001	.008	3	3
STAD	MRM3 →	+0.593	+3.203	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,934 associations by consensus.

H2BC2P by IRAK2 expression — LUAD

Explore this box plot interactively →