IRAK2

Across TCGA patient cohorts, IRAK2 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRAK2-associated genes across cancer lineages are c-Kit, Acetyl-a-Tubulin-Lys40, and Notch1. Each is linked with IRAK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both IRAK2-to-partner and partner-to-IRAK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by IRAK2-low versus IRAK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAK2→partner) and Y-score (partner→IRAK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Kit →	-0.185	-1.680	.027	.042	3	3
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.383	+1.584	.036	.019	3	2
UCEC	Notch1 →	+0.168	+1.495	<.001	.034	3	2
UCEC	PCNA →	+0.216	+1.925	.005	.005	3	2
UCEC	Annexin-1 →	+0.531	+1.604	.005	.021	3	2
UCEC	TIGAR →	+0.133	+1.611	.015	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

c-Kit by IRAK2 expression — UCEC

Explore this box plot interactively →