IRAK2

Across TCGA cell cohorts, IRAK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,698 significant associations in total. BONE shows the largest number of these associations.

The most reproducible IRAK2-associated GO terms across cancer lineages are Intracellular receptor signaling pathway, Regulation of actin filament polymerization, and Positive regulation of canonical NF-kappaB signal transduction. Each is linked with IRAK2 in more than 13 cancer types. Because this analysis shows association rather than direction, both IRAK2-to-partner and partner-to-IRAK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intracellular receptor signaling pathway grouped by IRAK2-low versus IRAK2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAK2→partner) and Y-score (partner→IRAK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Intracellular receptor signaling pathway →	+0.048	+1.219	<.001	.001	3	14
PANCREAS	Regulation of actin filament polymerization →	+0.076	+1.035	<.001	.001	3	13
LIVER	Positive regulation of canonical NF-kappaB signal transduction →	+0.095	+2.254	<.001	<.001	3	13
BREAST	Negative regulation of immune response →	+0.098	+1.823	<.001	<.001	3	13
LIVER	Cytoplasmic pattern recognition receptor signaling pathway →	+0.084	+1.608	.001	.002	3	12
BREAST	Regulation of blood coagulation →	+0.212	+2.116	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,698 associations by consensus.

Intracellular receptor signaling pathway by IRAK2 expression — PANCREAS

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