IRAK1BP1

Across TCGA patient cohorts, IRAK1BP1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRAK1BP1-associated genes across cancer lineages are Ku80, Rad50, and Tuberin. Each is linked with IRAK1BP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRAK1BP1-to-partner and partner-to-IRAK1BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by IRAK1BP1-low versus IRAK1BP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAK1BP1→partner) and Y-score (partner→IRAK1BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.311	+3.009	.012	.019	3	1
UCEC	Rad50 →	-0.289	-3.321	.023	.010	3	1
UCEC	Tuberin →	+0.462	+3.321	.001	.010	3	1
UCEC	JNK2 →	+0.392	+3.321	<.001	.010	2	1
UCEC	Caspase-8 →	-0.267	-3.321	.043	.010	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Ku80 by IRAK1BP1 expression — UCEC

Explore this box plot interactively →