IRAK1

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IRAK1 mutation is significantly associated with the RNA expression of many other genes, with 2,991 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRAK1-associated genes across cancer lineages are DNAJA1P5, RNU6-183P, and LINC01501. Each is linked with IRAK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRAK1-to-partner and partner-to-IRAK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAK1→partner) and Y-score (partner→IRAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CESCDNAJA1P5 →+0.182+4.839<.001<.00132
CESCRNU6-183P →+0.228+4.569<.001.00532
CESCLINC01501 →+0.120+3.844.006.00432
SKCMRNU6-956P →+1.032+5.054<.001<.00132
LUADLINC02049 →+0.062+5.523<.001.00132
HNSCRNU6-592P →+0.311+6.132<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,991 associations by consensus.

Exploration