Across TCGA patient cohorts, IRAK1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRAK1-associated genes across cancer lineages are JNK_pT183_Y185, 14-3-3_beta, and eEF2. Each is linked with IRAK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRAK1-to-partner and partner-to-IRAK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAK1→partner) and Y-score (partner→IRAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.172	-2.115	.007	.016	3	2
UCEC	14-3-3_beta →	-0.106	-3.558	.006	.002	3	1
UCEC	eEF2 →	+0.414	+3.459	.002	.005	3	1
UCEC	EGFR_pY1068 →	-0.257	-2.700	.007	.006	3	1
UCEC	eIF4E →	+0.271	+3.906	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.157	-2.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

IRAK1 survival (RNA) · tumor vs normal (RNA) · all IRAK1 data types