IRAG2

Across TCGA patient cohorts, IRAG2 mutation is significantly associated with the RNA expression of many other genes, with 1,438 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRAG2-associated genes across cancer lineages are PSAT1P4, IFNA1, and MIR584. Each is linked with IRAG2 in more than 2 cancer types. Because this analysis shows association rather than direction, both IRAG2-to-partner and partner-to-IRAG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSAT1P4 grouped by IRAG2-low versus IRAG2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAG2→partner) and Y-score (partner→IRAG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PSAT1P4 →	+0.259	+4.463	.001	.002	3	3
COAD	IFNA1 →	+0.176	+3.681	<.001	.009	3	2
READ	MIR584 →	+0.895	+5.039	<.001	.008	3	2
BLCA	RNU6-879P →	+0.461	+3.241	.001	.009	3	2
BLCA	RNU6-455P →	+0.399	+3.850	<.001	.004	3	2
UCEC	FRAT1 →	-0.448	-2.633	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,438 associations by consensus.

PSAT1P4 by IRAG2 expression — COAD

Explore this box plot interactively →