IRAG2

Across TCGA patient cohorts, IRAG2 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRAG2-associated genes across cancer lineages are JNK2, ATM, and Caspase-7-cleavedD198. Each is linked with IRAG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRAG2-to-partner and partner-to-IRAG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by IRAG2-low versus IRAG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAG2→partner) and Y-score (partner→IRAG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.217	+1.514	.001	.015	3	2
UCEC	ATM →	-0.482	-1.807	.001	.004	3	2
UCEC	Caspase-7-cleavedD198 →	+0.639	+1.926	.001	.008	3	2
UCEC	Caspase-8 →	-0.203	-2.195	.018	.009	3	2
SKCM	Syk →	-0.671	-2.321	.006	.035	3	1
SKCM	CDK1 →	+0.245	+2.321	.004	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

JNK2 by IRAG2 expression — UCEC

Explore this box plot interactively →