IRAG2

Across TCGA cell cohorts, IRAG2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,239 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible IRAG2-associated GO terms across cancer lineages are Insulin-like growth factor receptor signaling pathway, Negative regulation of RNA catabolic process, and Cellular response to insulin stimulus. Each is linked with IRAG2 in more than 6 cancer types. Because this analysis shows association rather than direction, both IRAG2-to-partner and partner-to-IRAG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Insulin-like growth factor receptor signaling pathway grouped by IRAG2-low versus IRAG2-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAG2→partner) and Y-score (partner→IRAG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Insulin-like growth factor receptor signaling pathway →	+0.073	+0.303	.001	.005	3	7
URINARY_TRACT	Negative regulation of RNA catabolic process →	+0.056	+1.996	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	Cellular response to insulin stimulus →	+0.062	+0.387	<.001	.001	2	7
KIDNEY	Mitochondrial electron transport, cytochrome c to oxygen →	+0.078	+0.391	.001	.005	3	6
CNS	Regulation of translational initiation →	+0.065	+0.380	<.001	<.001	3	6
BLOOD_Lymphoma	Lactate transport →	-0.129	-2.768	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,239 associations by consensus.

Insulin-like growth factor receptor signaling pathway by IRAG2 expression — SKIN

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