IRAG2

Across TCGA cell cohorts, IRAG2 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IRAG2-associated genes across cancer lineages are KRTAP10-7, CEP41, and GOT1. Each is linked with IRAG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRAG2-to-partner and partner-to-IRAG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-7 grouped by IRAG2-low versus IRAG2-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAG2→partner) and Y-score (partner→IRAG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KRTAP10-7 →	+0.026	+5.285	<.001	.003	3	1
LARGE_INTESTINE	CEP41 →	-1.074	-3.169	<.001	.009	3	1
LARGE_INTESTINE	GOT1 →	+0.676	+3.364	.002	.002	3	1
LARGE_INTESTINE	RBPMS →	-1.964	-3.278	<.001	.006	3	1
LARGE_INTESTINE	TTC14 →	-1.035	-3.278	<.001	.006	3	1
LARGE_INTESTINE	EEF2 →	+0.497	+3.364	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

KRTAP10-7 by IRAG2 expression — STOMACH

Explore this box plot interactively →