IRAG1

Across TCGA patient cohorts, IRAG1 mutation is significantly associated with the RNA expression of many other genes, with 3,146 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IRAG1-associated genes across cancer lineages are RNA5SP88, ATF4, and CTBP2P9. Each is linked with IRAG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both IRAG1-to-partner and partner-to-IRAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP88 grouped by IRAG1-low versus IRAG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAG1→partner) and Y-score (partner→IRAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP88 →	+0.305	+2.186	<.001	.005	3	3
UCEC	ATF4 →	+0.412	+2.747	<.001	<.001	3	3
READ	CTBP2P9 →	+0.052	+6.257	<.001	.001	3	2
SKCM	DAPK3 →	+0.450	+2.512	<.001	.001	3	2
UCEC	HDGFL2 →	+0.427	+2.584	<.001	<.001	3	2
UCEC	PUSL1 →	+0.406	+2.459	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,146 associations by consensus.

RNA5SP88 by IRAG1 expression — UCEC

Explore this box plot interactively →