IRAG1

Across TCGA cell cohorts, IRAG1 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IRAG1-associated genes across cancer lineages are CXorf51A, H2BW1, and PROP1. Each is linked with IRAG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IRAG1-to-partner and partner-to-IRAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CXorf51A grouped by IRAG1-low versus IRAG1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IRAG1→partner) and Y-score (partner→IRAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CXorf51A →	+0.212	+4.867	<.001	.009	3	2
BREAST	H2BW1 →	+0.095	+4.421	.002	.004	3	2
LARGE_INTESTINE	PROP1 →	+0.023	+2.791	<.001	.005	3	2
SOFT_TISSUE	AWAT2 →	+0.059	+4.142	.009	.003	3	1
SOFT_TISSUE	SYCP1 →	+0.028	+3.865	.003	.006	3	1
SOFT_TISSUE	PRR20B →	+0.026	+4.392	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

CXorf51A by IRAG1 expression — BLOOD_Lymphoma

Explore this box plot interactively →