IQUB

Across TCGA patient cohorts, IQUB RNA expression is significantly associated with the protein abundance of many other proteins, with 12,460 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IQUB-associated proteins across cancer lineages are LZTFL1, WDR35, and IFT46. Each is linked with IQUB in more than 6 cancer types. Because this analysis shows association rather than direction, both IQUB-to-partner and partner-to-IQUB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IQUB versus LZTFL1 in BRCA, with a Pearson correlation of 0.57.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IQUB→partner) and Y-score (partner→IQUB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LZTFL1 →	+0.558	+0.403	<.001	<.001	3	7
UCEC	WDR35 →	+0.451	+1.417	<.001	<.001	3	7
OV	IFT46 →	+0.513	+0.523	<.001	.002	3	7
UCEC	DYNC2H1 →	+0.553	+1.077	<.001	<.001	3	7
UCEC	IFT122 →	+0.396	+1.343	<.001	<.001	3	7
UCEC	IFT140 →	+0.470	+1.416	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,460 associations by consensus.

IQUB vs LZTFL1 — BRCA

Explore this scatter interactively →