IQUB

Across TCGA patient cohorts, IQUB mutation is significantly associated with the RNA expression of many other genes, with 4,155 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQUB-associated genes across cancer lineages are ZIC5, CCDC51, and FAM210A. Each is linked with IQUB in more than 3 cancer types. Because this analysis shows association rather than direction, both IQUB-to-partner and partner-to-IQUB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZIC5 grouped by IQUB-low versus IQUB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQUB→partner) and Y-score (partner→IQUB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZIC5 →	+0.933	+1.963	<.001	<.001	3	4
UCEC	CCDC51 →	+0.399	+3.108	.001	<.001	3	4
UCEC	FAM210A →	+0.401	+2.043	<.001	.004	3	4
UCEC	ZIC2 →	+1.750	+1.801	<.001	.001	3	4
UCEC	FANCB →	+0.406	+2.662	<.001	<.001	3	3
UCEC	GAS2L1 →	+0.382	+2.129	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,155 associations by consensus.

ZIC5 by IQUB expression — UCEC

Explore this box plot interactively →