IQUB

Across TCGA patient cohorts, IQUB mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IQUB-associated genes across cancer lineages are eIF4E, Notch1, and PDCD4. Each is linked with IQUB in more than 1 cancer types. Because this analysis shows association rather than direction, both IQUB-to-partner and partner-to-IQUB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by IQUB-low versus IQUB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQUB→partner) and Y-score (partner→IQUB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.187	+3.598	.006	.001	3	2
UCEC	Notch1 →	+0.181	+2.179	<.001	.001	3	2
UCEC	PDCD4 →	-0.513	-1.584	<.001	.032	3	2
UCEC	TFRC →	+0.507	+3.584	.003	.002	3	2
UCEC	ATM →	-0.638	-2.893	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.563	+1.785	.003	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

eIF4E by IQUB expression — UCEC

Explore this box plot interactively →