IQSEC3P1

Across TCGA pan-cancer cohorts, IQSEC3P1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated IQSEC3P1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IQSEC3P1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IQSEC3P1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRP show a favorable association.

HNSC, THCA, and KIRP are the cancer types where IQSEC3P1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.810	0.591	<.001	124	view →
THCA	OS	Tertile	II,III,IV	0.868	0.984	<.001	60	view →
KIRP	DFS	Tertile	All	1.000	0.755	.003	42	view →
COAD	OS	Tertile	All	0.806	0.891	.002	31	view →
DLBC	DFS	Quartile	All	0.572	0.883	.006	19	view →
UCEC	OS	Tertile	IV	0.961	0.640	.040	12	view →
PRAD	DFS	Tertile	All	0.825	0.906	.010	10	view →
GBM	DFS	Quartile	All	0.339	0.213	.032	9	view →
TGCT	DFS	Median	All	0.539	0.783	.025	8	view →
ACC	OS	Tertile	IV	0.782	0.284	.024	7	view →
CHOL	OS	Tertile	II,III,IV	0.587	1.000	.027	6	view →
THYM	DFS	Tertile	III,IV	1.000	0.540	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

IQSEC3P1–HNSC (DFS)

Open the HNSC breakdown →