IQSEC3

Across TCGA pan-cancer cohorts, IQSEC3 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IQSEC3 data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher IQSEC3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IQSEC3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, UCEC, and BLCA are the cancer types where IQSEC3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	All	0.969	0.623	.008	16	view →
BLCA	DFS	Median	III,IV	0.094	0.489	.005	15	view →
ESCA	OS	Median	All	0.022	0.701	<.001	12	view →
LUSC	DFS	Median	All	0.135	0.712	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IQSEC3–THYM (OS)

Open the THYM breakdown →