IQSEC3

Across TCGA patient cohorts, IQSEC3 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,676 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IQSEC3-associated proteins across cancer lineages are HSPA12B, EPB41L3, and FMNL3. Each is linked with IQSEC3 in more than 5 cancer types. Because this analysis shows association rather than direction, both IQSEC3-to-partner and partner-to-IQSEC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IQSEC3 versus HSPA12B in UCEC, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IQSEC3→partner) and Y-score (partner→IQSEC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSPA12B →	+0.526	+0.500	<.001	<.001	3	6
GBM	EPB41L3 →	+0.512	+0.803	<.001	<.001	3	5
UCEC	FMNL3 →	+0.552	+0.603	<.001	<.001	3	5
UCEC	ARHGEF17 →	+0.441	+0.486	<.001	<.001	3	5
GBM	PALM →	+0.676	+0.994	<.001	<.001	3	5
GBM	SPTBN1 →	+0.350	+0.759	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,676 associations by consensus.

IQSEC3 vs HSPA12B — UCEC

Explore this scatter interactively →