IQSEC3

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IQSEC3 protein abundance is significantly associated with the RNA expression of many other genes, with 5,124 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IQSEC3-associated genes across cancer lineages are FGF12, ABCG2, and HMGCLL1. Each is linked with IQSEC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IQSEC3-to-partner and partner-to-IQSEC3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IQSEC3 versus FGF12 in GBM, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQSEC3→partner) and Y-score (partner→IQSEC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMFGF12 →+0.999+0.416<.001.00132
CCRCCABCG2 →+0.999+0.617.002<.00132
CCRCCHMGCLL1 →+0.896+0.871<.001<.00132
CCRCCSLC22A8 →+0.818+0.787<.001<.00132
GBMCSMD3 →+1.137+0.562<.001<.00132
CCRCCANKRD46 →+0.472+0.668.001.00532
Each partner links to its Q-omics profile. Showing the 6 strongest of 5,124 associations by consensus.

IQSEC3 vs FGF12 — GBM

Per-sample scatter of IQSEC3 vs FGF12 in GBM (Pearson r = 0.41).

Explore this scatter interactively →

Exploration