IQSEC3

Across TCGA cell cohorts, IQSEC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,089 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IQSEC3-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Regulation of myoblast fusion. Each is linked with IQSEC3 in more than 8 cancer types. Because this analysis shows association rather than direction, both IQSEC3-to-partner and partner-to-IQSEC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by IQSEC3-low versus IQSEC3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IQSEC3→partner) and Y-score (partner→IQSEC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.113	+0.087	<.001	.002	3	9
LUNG_SCLC	Negative regulation of syncytium formation by plasma membrane fusion →	+0.111	+1.914	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.100	+0.102	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of RNA splicing →	+0.065	+0.083	.002	.005	3	7
UPPER_AERODIGESTIVE_TRACT	Regulation of syncytium formation by plasma membrane fusion →	+0.088	+0.101	<.001	<.001	3	7
BLOOD_Leukemia	Mitochondrial electron transport, cytochrome c to oxygen →	+0.066	+1.062	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,089 associations by consensus.

Negative regulation of myoblast fusion by IQSEC3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →