IQSEC3

Across TCGA cell cohorts, IQSEC3 mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IQSEC3-associated genes across cancer lineages are MAGEB4, TCP11X1, and RBMY1J. Each is linked with IQSEC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IQSEC3-to-partner and partner-to-IQSEC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by IQSEC3-low versus IQSEC3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQSEC3→partner) and Y-score (partner→IQSEC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	2
LUNG_NSCLC_LUAD	TCP11X1 →	+0.012	+3.604	<.001	.004	3	2
SKIN	RBMY1J →	+0.003	+2.977	<.001	.006	3	2
CNS	OR2D2 →	+0.034	+3.978	.006	.005	3	2
SOFT_TISSUE	CST9L →	+0.021	+4.369	<.001	.008	3	1
SOFT_TISSUE	RLN3 →	+0.044	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

MAGEB4 by IQSEC3 expression — LARGE_INTESTINE

Explore this box plot interactively →