IQSEC2

Across TCGA patient cohorts, IQSEC2 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,212 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible IQSEC2-associated proteins across cancer lineages are RNGTT, RPL15, and RPL26. Each is linked with IQSEC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both IQSEC2-to-partner and partner-to-IQSEC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IQSEC2 versus RNGTT in GBM, with a Pearson correlation of -0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IQSEC2→partner) and Y-score (partner→IQSEC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RNGTT →	-0.355	-0.869	.001	<.001	3	4
OV	RPL15 →	-0.277	-0.560	.005	.002	3	4
LUAD	RPL26 →	-0.548	-0.443	.001	.001	3	4
LUAD	RPL6 →	-0.360	-0.448	.001	<.001	3	4
LUAD	RPS9 →	-0.279	-0.459	<.001	.001	3	4
LSCC	SLC9A7 →	+0.496	+0.385	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,212 associations by consensus.

IQSEC2 vs RNGTT — GBM

Explore this scatter interactively →