IQSEC2

Across TCGA patient cohorts, IQSEC2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,591 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible IQSEC2-associated genes across cancer lineages are RPL26P29, HIGD1AP17, and STYK1. Each is linked with IQSEC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both IQSEC2-to-partner and partner-to-IQSEC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IQSEC2 versus RPL26P29 in UCEC, with a Pearson correlation of -0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQSEC2→partner) and Y-score (partner→IQSEC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL26P29 →	-0.712	-0.244	.005	.002	3	4
UCEC	HIGD1AP17 →	-0.980	-0.306	<.001	<.001	3	4
UCEC	STYK1 →	+0.857	+0.277	.003	<.001	3	4
BRCA	LGALS3BP →	+0.921	+0.292	<.001	.001	3	4
CCRCC	ATP8B3 →	+1.242	+0.308	<.001	<.001	3	4
LSCC	CXorf38 →	+0.473	+0.339	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,591 associations by consensus.

IQSEC2 vs RPL26P29 — UCEC

Explore this scatter interactively →