IQSEC2

Across TCGA cell cohorts, IQSEC2 RNA expression is significantly associated with the RNA expression of many other genes, with 9,485 significant associations in total. CNS shows the largest number of these associations.

The most reproducible IQSEC2-associated genes across cancer lineages are TFE3, ORAI3, and WDR13. Each is linked with IQSEC2 in more than 12 cancer types. Because this analysis shows association rather than direction, both IQSEC2-to-partner and partner-to-IQSEC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IQSEC2 versus TFE3 in LIVER, with a Pearson correlation of 0.64.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQSEC2→partner) and Y-score (partner→IQSEC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TFE3 →	+1.366	+2.321	.001	<.001	2	13
OESOPHAGUS	ORAI3 →	+1.607	+1.059	<.001	<.001	3	9
URINARY_TRACT	WDR13 →	+1.303	+1.409	<.001	<.001	3	9
LUNG_NSCLC_LUSC	MVP →	+2.891	+2.011	.001	<.001	3	9
LUNG_NSCLC_LUSC	NACC2 →	+1.508	+1.666	<.001	<.001	3	8
URINARY_TRACT	ZBTB4 →	+0.844	+1.427	<.001	<.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,485 associations by consensus.

IQSEC2 vs TFE3 — LIVER

Explore this scatter interactively →