IQSEC2

Across TCGA cell cohorts, IQSEC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,767 significant associations in total. CNS shows the largest number of these associations.

The most reproducible IQSEC2-associated GO terms across cancer lineages are Response to hydrostatic pressure, Regulation of protein localization to plasma membrane, and Golgi to plasma membrane protein transport. Each is linked with IQSEC2 in more than 11 cancer types. Because this analysis shows association rather than direction, both IQSEC2-to-partner and partner-to-IQSEC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to hydrostatic pressure grouped by IQSEC2-low versus IQSEC2-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IQSEC2→partner) and Y-score (partner→IQSEC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Response to hydrostatic pressure →	+0.125	+0.757	.001	.006	3	12
LUNG_NSCLC_LUSC	Regulation of protein localization to plasma membrane →	+0.101	+1.805	.002	.002	3	12
LUNG_NSCLC_LUSC	Golgi to plasma membrane protein transport →	+0.128	+1.297	.002	.002	3	11
CNS	Glycoprotein catabolic process →	+0.144	+1.531	<.001	<.001	3	10
LUNG_NSCLC_LUAD	Response to water →	+0.161	+1.515	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Vesicle-mediated transport to the plasma membrane →	+0.057	+1.548	.002	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,767 associations by consensus.

Response to hydrostatic pressure by IQSEC2 expression — BLOOD_Lymphoma

Explore this box plot interactively →