IQSEC2

Across TCGA cell cohorts, IQSEC2 mutation is significantly associated with the RNA expression of many other genes, with 314 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IQSEC2-associated genes across cancer lineages are REG1B, A3GALT2, and SLC32A1. Each is linked with IQSEC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IQSEC2-to-partner and partner-to-IQSEC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by IQSEC2-low versus IQSEC2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQSEC2→partner) and Y-score (partner→IQSEC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	REG1B →	+0.343	+5.169	<.001	.001	3	2
BLOOD_Lymphoma	A3GALT2 →	+0.030	+4.191	<.001	.007	3	2
BLOOD_Leukemia	SLC32A1 →	+0.699	+3.901	<.001	.006	3	2
BLOOD_Leukemia	NPSR1 →	+0.028	+4.567	<.001	.001	3	2
BLOOD_Leukemia	C1orf146 →	+0.028	+3.769	.009	.008	3	2
LARGE_INTESTINE	AKAP3 →	+0.823	+3.364	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 314 associations by consensus.

REG1B by IQSEC2 expression — BLOOD_Lymphoma

Explore this box plot interactively →