IQSEC2

Across TCGA cell cohorts, IQSEC2 mutation is significantly associated with the mutation status of many other genes, with 4,268 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IQSEC2-associated genes across cancer lineages are GLI2, CACNA1H, and SLC26A8. Each is linked with IQSEC2 in more than 5 cancer types. Because this analysis shows association rather than direction, both IQSEC2-to-partner and partner-to-IQSEC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLI2 grouped by IQSEC2-low versus IQSEC2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IQSEC2→partner) and Y-score (partner→IQSEC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GLI2 →	+5.066	+4.502	.007	.007	1	6
BLOOD_Lymphoma	CACNA1H →	+2.510	+3.502	.004	.004	1	5
OVARY	SLC26A8 →	+4.467	+3.240	.004	.004	1	5
BLOOD_Leukemia	CHPF2 →	+4.083	+3.338	.003	.003	1	5
OVARY	SPEG →	+2.204	+2.791	.005	.005	1	5
BREAST	MYH8 →	+3.754	+3.222	.001	.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,268 associations by consensus.

GLI2 by IQSEC2 expression — SOFT_TISSUE

Explore this box plot interactively →